Comedian Adam Cayton-Holland: “I don’t really have a joke about it. It’s more like a public service announcement that I make into the microphone, urging people to seek help, urging people to not feel ashamed of feeling powerless when it comes to their brains. You can see the audience tense up. I pepper in a few jokes here and there, to try to cut the tension. Which kind of works. It’s not perfect, but it’s real.”